Mentat Wiki: Smart Drug

Last major edit (later minor edits)

Added:

> * [http://www.braintropic.com The Complete Guide to Nootropics]

Changed:

< |'''Aniracetam'''|mechanism|effect|dosage|[http://jop.sagepub.com/content/4/4/219.short][http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-475J8YF-2G5&_user=10&_coverDate=05%2F31%2F1985&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1648669111&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a63fe53d944db4939f83c9c63934342e&searchtype=a][http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-477XNGW-CV&_user=10&_coverDate=07%2F31%2F1987&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1648667448&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6000ee3b662f0924c00ceb46fc59d9fd&searchtype=a][http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-477XNGW-CV&_user=10&_coverDate=07%2F31%2F1987&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1648667448&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6000ee3b662f0924c00ceb46fc59d9fd&searchtype=a][http://www.braintropic.com/nootropics/aniracetam/]|

to

> |'''Aniracetam'''|mechanism|effect|750 mg - 1500 mg|[http://jop.sagepub.com/content/4/4/219.short][http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-475J8YF-2G5&_user=10&_coverDate=05%2F31%2F1985&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1648669111&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a63fe53d944db4939f83c9c63934342e&searchtype=a][http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-477XNGW-CV&_user=10&_coverDate=07%2F31%2F1987&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1648667448&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6000ee3b662f0924c00ceb46fc59d9fd&searchtype=a][http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-477XNGW-CV&_user=10&_coverDate=07%2F31%2F1987&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1648667448&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6000ee3b662f0924c00ceb46fc59d9fd&searchtype=a][http://www.braintropic.com/nootropics/aniracetam/]|

Changed:

< |'''[http://phenylpiracetam Phenylpiracetam]'''|poorly characterized|antiamnesia, psychostimulatory effect|100-200mg|[http://www.brainprotips.com/phenylpiracetam/] [http://www.braintropic.com/nootropics/phenylpiracetam/]|

to

> |'''Pramiracetam'''|mechanism|effect|200 mg - 400 mg|[http://www.braintropic.com/nootropics/pramiracetam/]|
> |'''Phenylpiracetam'''|poorly characterized|antiamnesia, psychostimulatory effect|100-200mg|[http://www.brainprotips.com/phenylpiracetam/] [http://www.braintropic.com/nootropics/phenylpiracetam/]|

Changed:

< |'''Huperzine A'''|Inhibits Acetylcholinesterase[[BR]]Increases Acetylcholine levels|effect|dosage|source|
< |'''Vinpocetine'''|Inhibits Phospodiesterases[[BR]]Increases levels of cAMP, cGMP|effect|dosage|source|

to

> |'''Huperzine A'''|Inhibits Acetylcholinesterase[[BR]]Increases Acetylcholine levels|effect|50 mcg - 200 mcg|[http://www.braintropic.com/nootropics/huperzine-a/]|
> |'''Vinpocetine'''|Inhibits Phospodiesterases[[BR]]Increases levels of cAMP, cGMP|effect|5 mg - 10 mg|[http://www.braintropic.com/nootropics/vinpocetine/]|

Nootropics

NootropicsPrimer

Notes on Nootropics with evidence

Key resources

Studies on effectiveness of various Nootropics

Nefiracetam [1]
Bacopa monniera - [2]
Cytidine (5′)-diphosphocholine - [3]
Piracetam, aniracetam, meclofenoxate, fipexide - [4]

Other notes

Caffeine

Caffeine - a users guide to getting optimally wired

Ginseng

Page on Ginseng at healthyeatingclub.com - includes survey of scientific evidence

The information below is uncited - it would be good to collect links to specific studies to help assess which might be effective. ThufirHawat Citations are being added. *

: I advise reading them because I'm trying to include both supporting and detracting articles. Also, where info is sparse I include animal studies, and pathological studies - CassoX

Racetam Groups

Agent	Mechanism	Effect	Dosage	Citations
Piracetam	mechanism	effect	1600 mg - 9600 mg	[5][6][7][8][9][10]
Aniracetam	mechanism	effect	750 mg - 1500 mg	[11][12][13][14][15]
Oxiracetam	mechanism	effect	800mg - 1600mg	[16][17][18][19][20][21]
Nefiracetam	mechanism	effect	dosage	[22]
Pramiracetam	mechanism	effect	200 mg - 400 mg	[23]
Phenylpiracetam	poorly characterized	antiamnesia, psychostimulatory effect	100-200mg	[24] [25]

Inhibitors

Agent	Mechanism	Effect	Dosage	Citations
Huperzine A	Inhibits Acetylcholinesterase Increases Acetylcholine levels	effect	50 mcg - 200 mcg	[26]
Vinpocetine	Inhibits Phospodiesterases Increases levels of cAMP, cGMP	effect	5 mg - 10 mg	[27]
Galantamine	Inhibits Acetylcholinesterase Increases Acetylcholine levels	Effect	Dosage	source
L-Deprenyl	Inhibits MAO-B Increases Dopamine Levels	Effect	Dosage	source
Tolcapone	Inhibits COMT Increases Dopamine Levels Increases Epinephrine levels Increases Norepinephrine Levels	Effect	Dosage	source
2C-E	Inhibits MAO-B Increases Serotonin	Stimulant at low doses	Dose:5-10mg	source

Neuroreceptor Agents

Agent	Mechanism	Effect	Dosage	Citations
Hydergine	Stimulates dopaminergic and seratonergic receptors Inhibits Alpha Adrenoceptors Increases MAO levels	effect	dosage	source

Neurotransmitter Precursors

Agent	Mechanism	Effect	Dosage	Citations
5-HTP	Neurotransmitter precursor for Serotonin Increases serotonin levels	effect	dosage	source
DMAE	Neurotransmitter precursor for choline Increase Acetylcholine Levels	effect	dosage	source
Centrophenoxine	Neurotransmitter precursor for choline Increases acetylcholine levels Reduces Lipofuscins	effect	dosage	source
Acetyl-L-Carnitine	Neurotransmitter Precursor for Acetylcholine	Effect	Dosage	source
Alpha-GPC	Neurotransmitter Precursor for Choline	Effect	Dosage	source
Choline Citrate	Neurotransmitter Precursor for Acetylcholine	Effect	Dosage	source
Choline Bitartrate	Neurotransmitter Precursor for Acetylcholine	Effect	Dosage	source
Citicoline	Mechanism	Effect	Dosage	source

Stimulants

StimulantsPrimer?

Agent	Mechanism	Effect	Dosage	Citations
Caffeine	Mechanism	Effect	Dosage	source
Ritalin	Mechanism	Effect	Dosage	source
Adderal	Mechanism	Effect	Dosage	source
Modanifil	Mechanism	Effect	Dosage	[28]
Ephedra	Mechanism	Effect	Dosage	source

Essential Nutrition

NutrientsPrimer?

Amino Acids

Essential

Amino Acid	Function	Dosage	Citations
Isoleucine	Function	Dosage	source
Leucine	Function	Dosage	source
Lysine	Function	Dosage	source
Methionine	Function	Dosage	source
Phenylalanine	Function	Dosage	source
Threonine	Function	Dosage	source
Tryptophan	Function	Dosage	source
Valine	Function	Dosage	source
Arginine	Function	Dosage	source
Histidine	Function	Dosage	source

Nonessential

Amino Acid	Function	Dosage	Citations
Alanine	Function	Dosage	source
Asparagine	Function	Dosage	source
Aspartate	Function	Dosage	source
Cysteine	Function	Dosage	source
Glutamate	Function	Dosage	source
Glutamine	Function	Dosage	source
Glycine	Function	Dosage	source
Proline	Function	Dosage	source
Serine	Function	Dosage	source
Tyrosine	Function	Dosage	source

Nonstandard

Amino Acid	Function	Dosage	Citations
L-Dopa	Neurotransmitter Precursor for Dopamine Increases Dopamine Levels	Dosage	source

Essential Fatty Acids

Essential Vitamins

Agent	Mechanism	Effect	Dosage	Citations
Pantothenic Acid	Mechanism	Effect	Dosage	source

Essential Minerals

Miscellaneous

Agent	Mechanism	Effect	Dosage	Citations
Ginko Biloba	Mechanism	Effect	Dosage	source
Ginseng	Mechanism	Effect	Dosage	source
Mucuna Pruriens	Mechanism	Effect	Dosage	source
Yohimbe	Mechanism	Effect	Dosage	source